Association des personnes concernées par le tremblement essentiel

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Revue des publications scientifiques de SEPTEMBRE/OCTOBRE 2020

1 Managing Essential Tremor.
Hopfner F, Deuschl G. Neurotherapeutics. 2020 Sep 11. doi: 10.1007/s13311-020-00899-2. Online ahead of print. PMID: 32915385 Review.
Essential tremor is one of the most common tremor syndromes. According to the recent tremor classification, tremor as a symptom is defined as an involuntary, rhythmic, oscillatory move ment of a body part and is classified along two axes: axis 1- …
2  Tremor and Quality of Life in Patients With Advanced Essential Tremor Before and After Replacing Their Standard Deep Brain Stimulation With a Directional System.
Krüger MT, Avecillas-Chasin JM, Tamber MS, Heran MKS, Sandhu MK, Polyhronopoulos NE, Sarai N, Honey CR. Neuromodulation. 2020 Oct 24. doi: 10.1111/ner.13301. Online ahead of print. PMID: 33098185
OBJECTIVES: Patients with essential tremor treated with thalamic deep brain stimulation may experience increased tremor with the progression of their disease. …We aimed to compare the ability of a standard and a directional system to reduce tremor wi …
Sleep disorders in essential tremor: systematic review and meta-analysis.
Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín E, Agúndez JAG. Sleep. 2020 Sep 14;43(9):zsaa039. doi: 10.1093/sleep/zsaa039. PMID: 32163585
Sleep disorders are frequent in patients diagnosed with essential tremor (ET). The present review focuses on sleep disorders and the results of polysomnographic studies performed in patients with ET. For this purpose we performed a systematic review crossing the sea …
4  Post-diagnostic lived experiences of individuals with essential tremor.
Moore J, Eccles FJR, Simpson J. Disabil Rehabil. 2020 Oct;42(20):2894-2902. doi: 10.1080/09638288.2019.1574915. Epub 2019 Apr 11. PMID: 30973763
Purpose: This research study aimed to explore the lived experience of individuals with essential tremor.Method: This study was qualitative in nature and informed by interpretative phenomenological analysis methodology. …This study has highlighted the need for heal …
5  Essential tremor: Is the word “essential” really essential?
Lenka A, Louis ED. Parkinsonism Relat Disord. 2020 Oct 21;81:103-105. doi: 10.1016/j.parkreldis.2020.10.035. Online ahead of print. PMID: 33120070
Essential tremor (ET) is among the common movement disorders. A surge in research in recent years has considerably improved our understanding of disease etiology and pathogenesis, and its associated clinical phenomenology and natural history. …Amidst these various …
6  Tremor Research Group Essential Tremor Rating Scale (TETRAS): Assessing Impact of Different Item Instructions and Procedures.
Ondo WG, Pascual B; Tremor Research Group. Tremor Other Hyperkinet Mov (N Y). 2020 Oct 5;10:36. doi: 10.5334/tohm.64. PMID: 33101762 Free PMC article.
INTRODUCTION: The Tremor Research Group Essential Tremor Rating Scale (TETRAS) is a well-validate   d instrument to assess essential tremor. However, similar to all other tremor rating scales, specific instructions for individual tasks are b …
7  Rest tremor in dystonia: epidemiology, differential diagnosis, and pathophysiology.
Gupta N, Pandey S. Neurol Sci. 2020 Sep;41(9):2377-2388. doi: 10.1007/s10072-020-04402-9. Epub 2020 Apr 23. PMID: 32328831 Review.
BACKGROUND: The most common type of tremor reported in dystonia patients is postural and kinetic. There is uncertainty regarding the prevalence of rest tremor in dystonia. …Clinically, it is difficult to distinguish rest tremor in dystonia from other rest …
8  Distribution of tremor among the major degrees of freedom of the upper limb in subjects with Essential Tremor.
Pigg AC, Thompson-Westra J, Mente K, Maurer CW, Haubenberger D, Hallett M, Charles SK. Clin Neurophysiol. 2020 Nov;131(11):2700-2712. doi: 10.1016/j.clinph.2020.08.010. Epub 2020 Sep 2. PMID: 33010725
OBJECTIVE: Although Essential Tremor is one of the most common movement disorders, we do not currently know which muscles are most responsible for tremor. …CONCLUSIONS: This paper presents a thorough characterization of tremor distribution from the s …
9   Development and Validation of the Orthostatic Tremor Severity and Disability Scale (OT-10).
Merola A, Torres-Russotto DR, Stebbins GT, Vizcarra JA, Shukla AW, Hassan A, Marsili L, Krauss JK, Elble RJ, Deuschl G, Espay AJ. Mov Disord. 2020 Oct;35(10):1796-1801. doi: 10.1002/mds.28142. Epub 2020 Jun 20. PMID: 32562441
BACKGROUND: Limited tools are available for the assessment of orthostatic tremor severity and disability. OBJECTIVES: To develop and validate a self-administered orthostatic tremor scale. …CONCLUSIONS: The self-administered 10-item Orthostatic Tremor Severi …
10   Dysfunction of parvalbumin neurons in the cerebellar nuclei produces an action tremor.
Zhou M, Melin MD, Xu W, Südhof TC. J Clin Invest. 2020 Oct 1;130(10):5142-5156. doi: 10.1172/JCI135802. PMID: 32634124 Free article.
The tremor was rescued by completely blocking synaptic transmission with tetanus toxin in cerebellar nuclei, which also reversed the tremor phenotype in the traditional harmaline-induced essential tremor model. Using a promising animal model for action …
11  Möhwald K, Wuehr M, Schenkel F, Feil K, Strupp M, Schniepp R. J Neurol. 2020 Sep 11. doi: 10.1007/s00415-020-10177-y. Online ahead of print. PMID: 32915312
OBJECTIVE: To uncover possible impairments of walking and dynamic postural stability in patients with primary orthostatic tremor (OT). METHODS: Spatiotemporal gait characteristics were quantified in 18 patients with primary OT (mean age 70.5 5.9 years, 10 females) and 18 a …
12  Increased Purkinje Cell Complex Spike and Deep Cerebellar Nucleus Synchrony as a Potential Basis for Syndromic Essential Tremor. A Review and Synthesis of the Literature.
Handforth A, Lang EJ. Cerebellum. 2020 Oct 13. doi: 10.1007/s12311-020-01197-5. Online ahead of print. PMID: 33048308 Review.
We review advances in understanding Purkinje cell (PC) complex spike (CS) physiology that suggest increased CS synchrony underlies syndromic essential tremor (ET). We searched PubMed for papers describing factors that affect CS synchrony or cerebellar circuits poten …
13  Classification of Parkinson’s disease and essential tremor based on balance and gait characteristics from wearable motion sensors via machine learning techniques: a data-driven approach.
Moon S, Song HJ, Sharma VD, Lyons KE, Pahwa R, Akinwuntan AE, Devos H. J Neuroeng Rehabil. 2020 Sep 11;17(1):125. doi: 10.1186/s12984-020-00756-5. PMID: 32917244 Free PMC article.
BACKGROUND: Parkinson’s disease (PD) and essential tremor (ET) are movement disorders that can have similar clinical characteristics including tremor and gait difficulty. …
14  Neuropsychiatric Symptoms and Quality of Life in Patients With Adult-Onset Idiopathic Focal Dystonia and Essential Tremor.
Lee S, Chung SJ, Shin HW. Front Neurol. 2020 Sep 11;11:1030. doi: 10.3389/fneur.2020.01030. eCollection 2020. PMID: 33041977 Free PMC article.
Background: While idiopathic  focal dystonia (IFD) and essential tremor (ET) have been considered pure movement disorders, they reportedly induce neuropsychiatric manifestations and may thus be more accurately described as network disorders. …
15  Voxel-based morphometry and task functional magnetic resonance imaging in essential tremor: evidence for a disrupted brain network.
Boscolo Galazzo I, Magrinelli F, Pizzini FB, Storti SF, Agosta F, Filippi M, Marotta A, Mansueto G, Menegaz G, Tinazzi M. Sci Rep. 2020 Sep 15;10(1):15061. doi: 10.1038/s41598-020-69514-w. PMID: 32934259 Free PMC article.
The pathophysiology of essential tremor (ET) is controversial and might be further elucidated by advanced neuroimaging. …Homogeneous ET patients demonstrated deactivation patterns during tasks triggering tremor, encompassing a network of cortical and subcor …
16  Local Vibrational Therapy for Essential Tremor Reduction: A Clinical Study.
Abramavičius S, Venslauskas M, Vaitkus A, Gudžiūnas V, Laucius O, Stankevičius E. Medicina (Kaunas). 2020 Oct 21;56(10):552. doi: 10.3390/medicina56100552. PMID: 33096872 Free PMC article.
Background and objectives: tremor is an unintentional and rhythmic movement of any part of the body that is a typical symptom of Essential Tremor (ET). …Conclusions: the device reduces essential tremor in some patients and is safe to use in ET …
17  Comparing Programming Sessions of Vim-DBS.
Reitz SC, Luger S, Lapa S, Eibach M, Filmann N, Seifert V, Weise L, Klein JC, Kang JS, Baudrexel S, Quick-Weller J. Front Neurol. 2020 Sep 3;11:987. doi: 10.3389/fneur.2020.00987. eCollection 2020. PMID: 33013651 Free PMC article.
Background: Essential Tremor (ET) is a progressive neurological disorder characterized by postural and kinetic tremor most commonly affecting the hands and arms. …We investigated whether the location of the effective contact (most tremor suppression …
18  Ataxia and tolerance after thalamic deep brain stimulation for essential tremor.
Chiu SY, Nozile-Firth K, Klassen BT, Adams A, Lee K, Van Gompel JJ, Hassan A. Parkinsonism Relat Disord. 2020 Sep 10;80:47-53. doi: 10.1016/j.parkreldis.2020.09.009. Online ahead of print. PMID: 32950784
BACKGROUND: Deep brain stimulation (DBS) of the ventral intermediate nucleus (VIM) thalamus is highly effective to treat medication-refractory essential tremor (ET). Complications of stimulation-induced ataxia and tolerance have been reported in limited series, rang …
19  Botulinum toxin type A for hand tremor: a meta-analysis of randomised controlled trials.
Zheng X, Wei W, Liu P, Wu C, Lu L, Tang C. Neurol Neurochir Pol. 2020 Oct 13. doi: 10.5603/PJNNS.a2020.0079. Online ahead of print. PMID: 33047784 Free article.
Botulinum toxin type A (BoNT-A) has been widely used to treat tremor, but its efficacy and safety are uncertain. AIMS: To evaluate the efficacy and safety of BoNT-A in the treatment of hand tremor. …For clinical tremor scale scores, subgroup analyses sugges …
20  Advanced MRI techniques for transcranial high intensity focused ultrasound targeting.
Shah BR, Lehman VT, Kaufmann TJ, Blezek D, Waugh J, Imphean D, Yu FF, Patel TR, Chitnis S, Dewey RB, Maldjian JA, Chopra R. Brain. 2020 Sep 1;143(9):2664-2672. doi: 10.1093/brain/awaa107. PMID: 32537631
Magnetic resonance guided high intensity focused ultrasound is a novel, non-invasive, image-guided procedure that is able to ablate intracranial tissue with submillimetre precision. It is currently FDA approved for essential tremor and tremor dominant Parkins …
21  Deep Brain Stimulation for Facial Pain.
Singleton WGB, Ashida R, Patel NK. Prog Neurol Surg. 2020 Sep 9;35:1-21. doi: 10.1159/000509734. Online ahead of print. PMID: 32906139 Review.
Electro-modulation of subcortical deep brain structures by surgically implanted electrodes is now standard evidence-based treatment for movement disorders such as Parkinson’s disease and essential tremor and is approved for dystonia and obsessive-compulsive disorder …
22  Neural Representations of the Voice Tremor Spectrum.
de Lima Xavier L, Simonyan K. Mov Disord. 2020 Sep 25. doi: 10.1002/mds.28259. Online ahead of print. PMID: 32976662
Differential diagnosis of essential tremor of voice (ETv) is often challenging and includes dystonic tremor of voice (DTv), which is characterized by irregular, isometric contractions of laryngeal muscles during dystonic activity. Although clinical characteri …
23  Selective loss of the GABA(Aalpha1) subunit from Purkinje cells is sufficient to induce a tremor phenotype.
Nietz A, Krook-Magnuson C, Gutierrez H, Klein J, Sauve C, Hoff I, Christenson Wick Z, Krook-Magnuson E. J Neurophysiol. 2020 Oct 1;124(4):1183-1197. doi: 10.1152/jn.00100.2020. Epub 2020 Sep 9. PMID: 32902350
Previously, an essential tremor-like phenotype has been noted in animals with a global knockout of the GABA(Aalpha1) subunit. …This tremor mimicked the tremor seen in animals with a global knockout of the GABA(Aalpha1) subunit, and, like essential …
24  Comprehensive Evaluation of Voice-Specific Outcomes in Patients With Essential Tremor Before and After Deep Brain Stimulation.
Ruckart KW, Moya-Mendez ME, Nagatsuka M, Barry JL, Siddiqui MS, Madden LL. J Voice. 2020 Oct 15:S0892-1997(20)30354-4. doi: 10.1016/j.jvoice.2020.09.013. Online ahead of print. PMID: 33071149
OBJECTIVE: Deep brain stimulation (DBS) is a treatment for medically refractory essential tremor (ET), but there is a paucity of literature examining the effects of DBS on voice in patients with ET pre-DBS and post-DBS. …
25  An experience-based review of HIFU in functional interventional neuroradiology: transcranial MRgFUS thalamotomy for treatment of tremor.
Bruno F, Catalucci A, Arrigoni F, Sucapane P, Cerone D, Cerrone P, Ricci A, Marini C, Masciocchi C. Radiol Med. 2020 Sep;125(9):877-886. doi: 10.1007/s11547-020-01186-y. Epub 2020 Apr 7. PMID: 32266693 Review.
Tremor is a common and very disabling symptom in patients with essential tremor and Parkinson’s disease. In the recent years, transcranial ablation of thalamic nuclei using magnetic resonance guided high-intensity focused ultrasound has emerged as a minimally …
26  Quantifying Tremor in Essential Tremor Using Inertial Sensors-Validation of an Algorithm.
Mcgurrin P, Mcnames J, Wu T, Hallett M, Haubenberger D. IEEE J Transl Eng Health Med. 2020 Oct 21;9:2700110. doi: 10.1109/JTEHM.2020.3032924. eCollection 2021. PMID: 33150096 Free PMC article.
Background Assessment of essential tremor is often done by a trained clinician who observes the limbs during different postures and actions and subsequently rates the tremor. …It uses a two-stage approach that 1) estimates the tremor frequency of a s …
27  Multiparametric laryngeal assessment of the effect of thalamic deep brain stimulation on essential vocal tremor.
Erickson-DiRenzo E, Kuijper FM, Barbosa DAN, Lim EA, Lin PT, Lising MA, Huang Y, Sung CK, Halpern CH. Parkinsonism Relat Disord. 2020 Oct 13;81:106-112. doi: 10.1016/j.parkreldis.2020.10.026. Online ahead of print. PMID: 33120071
This work aims to conduct a multiparametric assessment of the effect of deep brain stimulation (DBS) of the thalamic ventral intermediate nucleus (VIM) on essential vocal tremor (EVT) and investigate the relation between DBS lead location and EVT outcomes. METHODS: …
28  The Pathophysiology of Dystonic Tremors and Comparison with Essential Tremor.
Panyakaew P, Cho HJ, Lee SW, Wu T, Hallett M. J Neurosci. 2020 Oct 22:JN-RM-1181-20. doi: 10.1523/JNEUROSCI.1181-20.2020. Online ahead of print. PMID: 33097635
There are two types of dystonic tremor syndromes (DTS), dystonic tremor (DT) and tremor associated with dystonia (TAWD), and neither is understood. DTS likely share some mechanisms with non-tremulous dystonia, and there may also be overlaps with essential …
29  Comparison between deep brain stimulation and magnetic resonance-guided focused ultrasound in the treatment of essential tremor: a systematic review and pooled analysis of functional outcomes.
Giordano M, Caccavella VM, Zaed I, Foglia Manzillo L, Montano N, Olivi A, Polli FM. J Neurol Neurosurg Psychiatry. 2020 Oct 14:jnnp-2020-323216. doi: 10.1136/jnnp-2020-323216. Online ahead of print. PMID: 33055140 Review.
The current gold standard surgical treatment for medication-resistant essential tremor (ET) is deep brain stimulation (DBS). However, recent advances in technologies have led to the development of incisionless techniques, such as magnetic resonance-guided focused ul …
30  Multi-Dimensional, Short-Timescale Quantification of Parkinson’s Disease and Essential Tremor Motor Dysfunction.
Sanderson JB, Yu JH, Liu DD, Amaya D, Lauro PM, D’Abreu A, Akbar U, Lee S, Asaad WF. Front Neurol. 2020 Sep 18;11:886. doi: 10.3389/fneur.2020.00886. eCollection 2020. PMID: 33071924 Free PMC article.
Additionally, these data were compared to analogous data generated from a separate group of 12 patients with essential tremor (ET) to assess the task’s specificity for different movement disorders. …Much of this difference was attributable to the homogenous, tr …
31  Gamma Knife stereotactic radiosurgery as a treatment for essential and parkinsonian tremor: long-term experience.
Pérez-Sánchez JR, Martínez-Álvarez R, Martínez Moreno NE, Torres Diaz C, Rey G, Pareés I, Del Barrio A A, Álvarez-Linera J, Kurtis MM. Neurologia. 2020 Sep 8:S0213-4853(20)30217-6. doi: 10.1016/j.nrl.2020.05.014. Online ahead of print. PMID: 32917436 Free article. English, Spanish.
INTRODUCTION: Unilateral Gamma Knife stereotactic radiosurgery on the ventral-intermediate nucleus of the thalamus is a minimally invasive neurosurgical option for refractory tremor. We describe the experience of Gamma Knife thalamotomy (GKT) in patients with essential …
32  MRI follow-up after magnetic resonance-guided focused ultrasound for non-invasive thalamotomy: the neuroradiologist’s perspective.
Keil VC, Borger V, Purrer V, Groetz SF, Scheef L, Boecker H, Schild HH, Kindler C, Schmitt A, Solymosi L, Wüllner U, Pieper CC. Neuroradiology. 2020 Sep;62(9):1111-1122. doi: 10.1007/s00234-020-02433-9. Epub 2020 May 3. PMID: 32363482 Free PMC article.
PURPOSE: Magnetic resonance-guided focused ultrasound (MRgFUS) systems are increasingly used to non-invasively treat tremor; consensus on imaging follow-up is poor in these patients. …METHODS: MRgFUS-induced lesions and oedema were retrospectively evaluated based on DWI, …
33  Do We Belittle Essential Tremor by Calling It a Syndrome Rather Than a Disease? No.
Elble RJ. Front Neurol. 2020 Sep 30;11:586606. doi: 10.3389/fneur.2020.586606. eCollection 2020. PMID: 33101188 Free PMC article.
Deviations from this definition should not be labeled as essential tremor. Patients with additional questionably-abnormal signs or with signs of uncertain relevance to tremor are classified as essential tremor plus. …The etiologies, pathology, …
34  Cerebello-thalamo-cortical network is intrinsically altered in essential tremor: evidence from a resting state functional MRI study.
Nicoletti V, Cecchi P, Pesaresi I, Frosini D, Cosottini M, Ceravolo R. Sci Rep. 2020 Oct 7;10(1):16661. doi: 10.1038/s41598-020-73714-9. PMID: 33028912 Free PMC article.
Cerebello-thalamo-cortical network is suggested to be involved in the pathophysiology of Essential Tremor (ET). 23 patients with ET and 23 matched HC underwent a 3T-MRI with acquisition of a resting state sequence. …The increased connectivity between cerebellum an
35  Two-year Follow-up Results of Magnetic Resonance Imaging-guided Focused Ultrasound Unilateral Thalamotomy for Medication-refractory Essential Tremor.
Ito H, Yamamoto K, Fukutake S, Odo T, Kamei T. Intern Med. 2020 Oct 15;59(20):2481-2483. doi: 10.2169/internalmedicine.4360-19. Epub 2020 Jul 7. PMID: 32641664 Free article.
We followed them for 2 years using the clinical rating scale for tremor (CRST) and the quality of life in essential tremor questionnaire (QUEST). Results Right-handed tremor improved immediately after the left Vim thalamotomy in all patients. …
Tantİk Pak A, ŞengÜl Y, Otcu Temur H, Alkan A. Turk J Med Sci. 2020 Oct 6. doi: 10.3906/sag-2004-305. Online ahead of print. PMID: 33021759 Free article.
BACKGROUND/AIM: Evolving definition of essential tremor (ET) introduced us a new concept of neurodegenerative disease pointing to diffuse brain network involvement with a wide spectrum of associated motor and non-motor symptoms. …Sociodemographic characteristics a …
37  Relative increase in cerebellar gray matter in young onset essential tremor: Evidence from voxel-based morphometry analysis.
Qi S, Cao H, Wang R, Jian Z, Bian Y, Yang J. J Clin Neurosci. 2020 Sep;79:251-256. doi: 10.1016/j.jocn.2020.07.003. Epub 2020 Aug 17. PMID: 33070906
This study is to investigate the presence of brain gray matter abnormalities in young onset essential tremor (ET) patients with arm tremor. Thirty ET patients together with 30 healthy voluntees were taken as candidates. Magnetic resonance imaging (MRI) was p …
38  Low Prevalence of NOTCH2NLC GGC Repeat Expansion in White Patients With Movement Disorders.
Yau WY, Vandrovcova J, Sullivan R, Chen Z, Zecchinelli A, Cilia R, Stefano D, Murray M, Carmona S; Genomics England Research Consortium, Chelban V, Ishiura H, Tsuji S, Jaunmuktane Z, Turner C, Wood NW, Houlden H. Mov Disord. 2020 Oct 7. doi: 10.1002/mds.28302. Online ahead of print. PMID: 33026126
METHODS: We searched for the GGC-repeat expansion in NOTCH2NLC using repeat-primed polymerase chain reaction in 203 patients with essential tremor, 825 patients with PD, 194 patients with spinocerebellar ataxia, 207 patients with “possible” or “probable” MSA, and 33 … 39
Neuroimaging Advances in Deep Brain Stimulation: Review of Indications, Anatomy, and Brain Connectomics.
Middlebrooks EH, Domingo RA, Vivas-Buitrago T, Okromelidze L, Tsuboi T, Wong JK, Eisinger RS, Almeida L, Burns MR, Horn A, Uitti RJ, Wharen RE Jr, Holanda VM, Grewal SS. AJNR Am J Neuroradiol. 2020 Sep;41(9):1558-1568. doi: 10.3174/ajnr.A6693. Epub 2020 Aug 13. PMID: 32816768 Review.
In this review, we use a combination of ultra-high-field MR imaging and diffusion tractography to highlight relevant anatomy for the currently approved indications for deep brain stimulation in the United States: essential tremor, Parkinson disease, drug-resistant e …
40 Fully implanted adaptive deep brain stimulation in freely moving essential tremor patients.
Ferleger BI, Houston B, Thompson MC, Cooper SS, Sonnet KS, Ko AL, Herron JA, Chizeck HJ. J Neural Eng. 2020 Oct 15;17(5):056026. doi: 10.1088/1741-2552/abb416. PMID: 33055369
OBJECTIVE: Deep brain stimulation (DBS) is a safe and established treatment for essential tremor (ET) and several other movement disorders. One approach to improving DBS therapy is adaptive DBS (aDBS), in which stimulation parameters are modulated in real time based …
41  Multimodal MRI for MRgFUS in essential tremor: post-treatment radiological markers of clinical outcome.
Kapadia AN, Elias GJB, Boutet A, Germann J, Pancholi A, Chu P, Zhong J, Fasano A, Munhoz R, Chow C, Kucharczyk W, Schwartz ML, Hodaie M, Lozano AM. J Neurol Neurosurg Psychiatry. 2020 Sep;91(9):921-927. doi: 10.1136/jnnp-2020-322745. Epub 2020 Jul 10. PMID: 32651242
BACKGROUND: MRI-guided focused ultrasound (MRgFUS) thalamotomy is a promising non-invasive treatment option for medication-resistant essential tremor. However, it has been associated with variable efficacy and a relatively high incidence of adverse effects. …Patie …
42  Transcranial magnetic resonance-guided focused ultrasound thalamotomy as a safe treatment option in multiple sclerosis patients with essential tremor.
Gagliardo C, Ragonese P, Iacopino GD, Salemi G, Midiri M, D’Amelio M. Neurol Sci. 2020 Oct 22. doi: 10.1007/s10072-020-04841-4. Online ahead of print. PMID: 33094429
Transcranial magnetic resonance-guided focused ultrasound is a recently introduced incisionless treating option for essential tremor and tremor-dominant idiopathic Parkinson disease. …Here, we report on two patients with multiple sclerosis with medication r …
43  Application of Deep Brain Stimulation for Treatment-Resistant Obsessive Compulsive Disorder: Current Status and Future Perspectives in Japan.
Yamasue H, Sugiyama K. Neurol Med Chir (Tokyo). 2020 Oct 16. doi: 10.2176/nmc.ra.2020-0196. Online ahead of print. PMID: 33071277 Free article.
As in many Western countries, deep brain stimulation (DBS) is already being used daily in Japan to clinically treat neurological diseases such as Parkinson’s disease, essential tremor, and dystonia. Additionally, in both Europe and the United States, numerous case r …
44   O-Arm Navigated Frameless and Fiducial-Less Deep Brain Stimulation.
Krahulík D, Nevrlý M, Otruba P, Bardoň J, Hrabálek L, Pohlodek D, Kaňovský P, Valošek J. Brain Sci. 2020 Sep 27;10(10):683. doi: 10.3390/brainsci10100683. PMID: 32992610 Free PMC article.
OBJECT: Deep brain stimulation (DBS) is a very useful procedure for the treatment of diopathic Parkinson’s disease (PD), essential tremor, and dystonia. The authors evaluated the accuracy of the new method used in their center for the placing of DBS electrodes. …
45  Intraoperative imaging findings in transcranial MR imaging-guided focused ultrasound treatment at 1.5T may accurately detect typical lesional findings correlated with sonication parameters.
Gagliardo C, Cannella R, Quarrella C, D’Amelio M, Napoli A, Bartolotta TV, Catalano C, Midiri M, Lagalla R. Eur Radiol. 2020 Sep;30(9):5059-5070. doi: 10.1007/s00330-020-06712-0. Epub 2020 Apr 28. PMID: 32346791
METHODS: Fifty prospectively enrolled patients undergoing unilateral tcMRgFUS thalamotomy for either medication-refractory essential tremor (n = 39) or Parkinson tremor (n = 11) were included. …
46  Brain Atrophy Following Deep Brain Stimulation: Management of a Moving Target.
Chiu SY, Deeb W, Zeilman P, Ramirez-Zamora A, Patterson A, Patel B, Foote KD, Okun MS, Patel A, Almeida L. Tremor Other Hyperkinet Mov (N Y). 2020 Oct 21;10:46. doi: 10.5334/tohm.546. PMID: 33133768 Free PMC article.
CLINICAL VIGNETTE: A 51-year-old man with essential tremor (ET) had bilateral ventralis intermedius nucleus deep brain stimulation (VIM-DBS) placed to address refractory tremor. Despite well-placed DBS leads and adequate tremor response, he subsequentl …
47  Faecal microbiota transplantation simultaneously ameliorated patient’s essential tremor and irritable bowel syndrome.
Liu XJ, Wu LH, Xie WR, He XX. Psychogeriatrics. 2020 Sep;20(5):796-798. doi: 10.1111/psyg.12583. Epub 2020 Jul 20. PMID: 32691508 Free PMC article. No abstract available.
48  Zonisamide-induced Choroidal Effusion: A Case Report.
Baradad Jurjo MC, Sanz Moreno S, Moix Gil E, Lillo Sopena J, Caminal Mitjana JM. J Glaucoma. 2020 Sep;29(9):e100-e102. doi: 10.1097/IJG.0000000000001596. PMID: 32649452
CASE REPORT: A 72-year-old woman presented with a 4-day history of bilateral blurred vision 9 days after initiating oral zonisamide for essential tremor. Clinical examination revealed an asymmetric choroidal detachment with open anterior chamber angle and intraocula …
49  Candidate variants in TUB are associated with familial tremor.
Sailani MR, Jahanbani F, Abbott CW, Lee H, Zia A, Rego S, Winkelmann J, Hopfner F, Khan TN, Katsanis N, Müller SH, Berg D, Lyman KM, Mychajliw C, Deuschl G, Bernstein JA, Kuhlenbäumer G, Snyder MP. PLoS Genet. 2020 Sep 21;16(9):e1009010. doi: 10.1371/journal.pgen.1009010. eCollection 2020 Sep. PMID: 32956375 Free PMC article.
Essential tremor (ET) is the most common adult-onset movement disorder. …
50  A Deep Brain Stimulation Trial Period for Treating Chronic Pain.
Shirvalkar P, Sellers KK, Schmitgen A, Prosky J, Joseph I, Starr PA, Chang EF. J Clin Med. 2020 Sep 29;9(10):3155. doi: 10.3390/jcm9103155. PMID: 33003443 Free PMC article. Review.
As the optimal brain target sites for various diseases (i.e., Parkinson’s disease, essential tremor) became better established, such trial periods have fallen out of favor. …
51  The Active Electrode in the Living Brain: The Response of the Brain Parenchyma to Chronically Implanted Deep Brain Stimulation Electrodes.
Evers J, Lowery M. Oper Neurosurg (Hagerstown). 2020 Oct 19:opaa326. doi: 10.1093/ons/opaa326. Online ahead of print. PMID: 33074305
BACKGROUND: Deep brain stimulation is an established symptomatic surgical therapy for Parkinson disease, essential tremor, and a number of other movement and neuropsychiatric disorders. …
52  Preoperative Magnetic Resonance Image Quality in Motion Disorder Patients Scheduled for Deep Brain Stimulation Surgery.
Ronde EM, Silvasti-Lundell M, Pekkola J, Tallgren M, Kivisaari R. Stereotact Funct Neurosurg. 2020 Sep 21:1-8. doi: 10.1159/000506998. Online ahead of print. PMID: 32957096
METHODS: The records of DBS procedures for Parkinson’s disease (PD), dystonia, and essential tremor in our tertiary neurosurgical unit between January 2011 and June 2016 were reviewe. …
53  Deep Brain Stimulation Generator Failure due to External Defibrillation in a Patient with Essential Tremor.
Davis G, Levine Z. Stereotact Funct Neurosurg. 2020 Oct 16:1-2. doi: 10.1159/000510122. Online ahead of print. PMID: 33070142
There exist only two case reports to date of open cardiac defibrillation with deep brain stimulator system (DBS) implantation. We report a 64-year-old male with DBS system in place for essential tremor who underwent cardiac defibrillation after cardiac arrest. After …
54  Brain TRODAT-SPECT Versus MRI Morphometry in Distinguishing Early Mild Parkinson’s Disease from Other Extrapyramidal Syndromes.
Hossein-Tehrani MR, Ghaedian T, Hooshmandi E, Kalhor L, Foroughi AA, Ostovan VR. J Neuroimaging. 2020 Sep;30(5):683-689. doi: 10.1111/jon.12740. Epub 2020 Jun 17. PMID: 32557946
CONCLUSION: (99m) Tc-TRODAT has a higher accuracy in differentiation of early PD from non-Parkinsonian conditions, particularly essential tremor. Olfactory bulbs volumetry by using MRI can also serve as a potential alternative method in this regard….
55  MRI-based thermal dosimetry based on single-slice imaging during focused ultrasound thalamotomy.
McDannold NJ, White PJ, Cosgrove GR. Phys Med Biol. 2020 Sep 11. doi: 10.1088/1361-6560/abb7c4. Online ahead of print. PMID: 32916666
Transcranial MRI-guided focused ultrasound (MRgFUS) is a noninvasive thermal ablation method approved for the treatment of essential tremor and tremor-dominant Parkinson’s disease. This method uses MR temperature imaging (MRTI) to monitor the treatment. …
56  Frequency-dependent spike-pattern changes in motor cortex during thalamic deep brain stimulation.
Bello EM 2nd, Agnesi F, Xiao Y, Dao J, Johnson MD. J Neurophysiol. 2020 Sep 23. doi: 10.1152/jn.00198.2020. Online ahead of print. PMID: 32965147
The cerebellar-receiving area of the motor thalamus is the primary anatomical target for treating essential tremor with deep brain stimulation (DBS). While neuroimaging studies have shown that higher stimulation frequencies in this target correlate with increased co …
57  Evaluation of Automatic Segmentation of Thalamic Nuclei through Clinical Effects Using Directional Deep Brain Stimulation Leads: A Technical Note.
Krüger MT, Kurtev-Rittstieg R, Kägi G, Naseri Y, Hägele-Link S, Brugger F. Brain Sci. 2020 Sep 17;10(9):642. doi: 10.3390/brainsci10090642. PMIDG, Naseri Y, Hägele-Link S, Brugger F. Brain Sci. 2020 Sep 17;10(9):642. doi: 10.3390/brainsci10090642. PMID: 32957437 Free PMC article.
We demonstrate an approach to evaluate the accuracy of such software for the ventral intermediate nucleus (VIM) using directional leads. In an essential tremor patient with asymmetrical brain anatomy, lead placement was adjusted according to the suggested segmentati …
58  NOTCH2NLC Intermediate-Length Repeat Expansions Are Associated with Parkinson Disease.
Shi CH, Fan Y, Yang J, Yuan YP, Shen S, Liu F, Mao CY, Liu H, Zhang S, Hu ZW, Fan LY, Li MJ, Fan SH, Liu XJ, Xu YM. Ann Neurol. 2020 Oct 5. doi: 10.1002/ana.25925. Online ahead of print. PMID: 33016348
Skin biopsy revealed phospho-alpha-synuclein deposition, confirming the PD diagnosis in 2 patients harboring intermediate-length repeat expansions instead of NIID or essential tremor. Fibroblasts from PD patients harboring intermediate-length repeat expansions revea …
59 Microelectrode Recording and Radiofrequency Thalamotomy following Focused Ultrasound Thalamotomy.
De Vloo P, Milosevic L, Gramer RM, Dallapiazza RF, Lee DJ, Fasano A, Hutchison WD, Lozano AM, Schwartz ML, Kalia SK. Stereotact Funct Neurosurg. 2020 Sep 16:1-4. doi: 10.1159/000510109. Online ahead of print. PMID: 32937628
Magnetic resonance imaging-guided focused ultrasound (MRgFUS) is a novel method for stereotactic brain lesioning and has primarily been applied for thalamotomies to treat essential tremor (ET). The electrophysiological properties of previously MRgFUS-sonicated thala …
60  Interference of subcutaneous implantable cardioverter defibrillator by deep brain stimulation.
Nayak HM, Sauser E, Xie T. Parkinsonism Relat Disord. 2020 Oct 11;81:75-77. doi: 10.1016/j.parkreldis.2020.10.018. Online ahead of print

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APPEL D’OFFRES A LA RECHERCHE SCIENTIFIQUE L’Association des personnes concernées par le tremblement essentiel (Aptes) lance un appel d’offres visant à soutenir un ou des projets de recherche portant sur les origines (facteurs génétiques, épidémiologiques…), les mécanismes physiopathologiques ou les développements diagnostiques ou thérapeutiques du tremblement essentiel. Toute proposition devra concerner le tremblement essentiel mais…

Jennifer et Bernard souffrent de tremblements essentiels. Cela se traduit par des mouvements incontrôlables des mains. Cette maladie neurologique gâche la vie de 300 000 personnes en France. Ils vont tous les deux bénéficier d’interventions hors du commun au cœur de leur cerveau.

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